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Welcome to the Sada Lab


Laboratory of Skin Regeneration and Aging

Medical Institute of Bioregulation, Kyushu University

IRCMS, Kumamoto University


Tissue stem cells maintain tissue integrity during homeostasis and exhibit remarkable plasticity in response to stresses and injuries. A misregulation of stem cells leads to tissue dysfunction, such as impaired wound healing, chronic inflammation, tumorigenesis, and aging. Emerging evidence suggests that stem cell populations in adult tissues are heterogeneous and play distinct roles in physiological and pathological conditions. 


Our research focuses on elucidating the cellular dynamics and regulatory mechanisms of tissue stem cells during skin regeneration, inflammation and aging processes. We have identified a novel stem cell population in mouse skin epidermis (Sada et al., Nat Cell Biol 2016) and established genetic tools and molecular markers to analyze these cells in vivo. Such stem cell proliferative heterogeneity is shown to be present not only in mouse skin, but also in the other epithelial tissues of the eye and oral mucosa, as well as in human skin. We are now combining cellular and molecular biology methods, mouse genetics, omics analysis, bioengineering, and glycobiology to analyze the function of biomolecules involved in skin stem cell regulation. Our research goal is to identify the drivers and effectors of stem cell dysfunction; targeting these factors will allow us to prevent and treat diseases at the stem cell level, with potential applications in regenerative therapies and future treatments for cancer, aging, and other skin diseases.


The Sada Laboratory is looking for motivated students (master's and doctoral level), post-doctoral fellows, and collaborators worldwide. If you are interested in pursuing research with us, please do not hesitate to contact us.





IRCMS symposium: Rise of Diversity in Science was held for two days at IRCMS, Kumamoto University. The theme of the symposium was diversity, and we had invited lectures and poster sessions by researchers with diverse topics, as well as a panel discussion during the power hour "Diversity for Discovery: Unlocking the Power of Different Perspectives”. Sada lab members actively participated and enjoyed the symposium. I think it was a good, stimulating meeting. Thank you to all the speakers and participants.



Aiko was invited to speak at the 2023 Inaugural meeting of ISRB: International Society for Regenerative Biology in Vienna. Enjoyed wonderful talks and the beautiful city of Vienna.



As of September 1, Dr. Mizuho Ishikawa has been appointed to the Medical Institute of Bioregulation, Kyushu University as an Assistant Professor. Congratulations! 



Second-year PhD students Wency, Thisakorn, and Thomson completed their interim presentations. Well done. We received a lot of feedback and we will do our best to further develop the research. 



As of July 1, Aiko has been appointed to the Medical Institute of Bioregulation, Kyushu University as a full professor. We will continue to do our best to advance our research in this new environment. 



Happy New Year! We welcome Ahmed, a visiting researcher from Egypt, who joined our lab in January. Looking forward to another wonderful year with all of you.



We attendedthe Molecular Biology Society of Japan 2022 at Makuhari Messe. It was very exciting conference! From Sada Lab, Nguyen and Ikuto gave poster presentations and Aiko gave a talk in the workshop. I was happy to see that alumni, Yen and Ryutaro are also doing well.

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