Welcome to the Sada Lab!​

Laboratory of Skin Regeneration and Aging

IRCMS, Kumamoto University, Japan

​ 

Stem cells maintain the tissue integrity during homeostasis and show remarkable plasticity to quickly respond to various stress or damages of the tissue. Dysfunction or misregulation of stem cells leads to tissue dysfunction, including impaired wound healing, cancer and aging. Emerging evidence suggests the presence of heterogeneous stem cell populations within adult tissues and their specific roles in physiological and pathological conditions. Our research focuses on elucidating the cellular dynamics and regulatory mechanisms of tissue-resident stem cells, especially using mouse epithelial tissues (skin, eyes, oral) as a model. We identified a new stem cell populations in the mouse skin epidermis (Sada et al., Nat Cell Biol 2016) and established the genetic tools and molecular markers to analyze these cells in vivo. We are currently studying stem cells in tissue regeneration and aging, by combining cell & molecular biology techniques, genetic-engineering of mice, omics analysis, FACS-based stem cell isolation, bioengineering, glycobiology and so on. Our research goal is to reveal the drivers and effectors of stem cell dysfunction. Targeting these factors may prevent or cure diseases at the stem cell level, with implications for applications in regenerative therapy and for future treatments of cancer, aging and other disorders.

Sada lab seeks motivated students (undergraduate, master and PhD level), postdocs and collaborators from all over the world. If you're interested in pursuing research with us, please do not hesitate to contact me!

RESEARCH INTEREST

Stem Cell Dynamics
Skin Biology
Stem Cell Aging
Mouse Model
Stem Cell Isolation
Tissue Engineering
Omics Analysis
Glycobiology
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RESEARCH ENVIRONMENT

International Research Center for Medical Sciences (IRCMS) at Kumamoto University is a a cutting edge, research institute, especially focusing on stem cells, aging and cancer. Researchers in our institute enjoy Science and closely communicate with each other in a characteristic open lab system of our institute. 

IRCMS website

http://ircms.kumamoto-u.ac.jp

An unofficial twitter account of Junior PIs in Kumamoto University. We tweet, at least once a day, about daily life in Kumamoto and our exciting research going on here.

https://twitter.com/NextGenPIs

LIFE IN KUMAMOTO

Kumamoto University is located in the south part of Japan (Kyushu area) and is close to the city center with traditional Japanese castle, convenient living places, shopping mall and nice foods & drinks! Kumamoto also has beautiful nature within 1 hour drive distance, where you can enjoy Aso mountains, hot springs, fishing and many other outdoor activities. 

Kumamoto has an official character, called "kumamon". You can meet our cute (and funny!) friend here in Kumamoto. https://kumamon-official.jp/kiji0035109/index.html

WHAT'S NEW

FUNDING

2020.9.11

Erna received a grant, JSPS KAKENHI, for research activity start-up. Congratulations!

FUNDING

2020.9.11

Aiko is selected for the interstellar initiative 2020. 

https://www.nyas.org/events/2020/the-interstellar-initiative-2020-2021-workshop-1/

FUNDING

2020.7.30

Aiko received a new grant, JSPS KEKENHI, Grant-in-Aid for Challenging Research (Exploratory) on glycan and skin stem cell aging project. We will keep going!

LAB NEWS

2020.7.23

We opened for entries of FY2020 IRCMS research internship program. If you are interested in, please contact me!

<Duration>

2 to 8 weeks between late October 2020 and early March 2021

<Application Period>

July 20th (Mon) to August 31st (Mon), 2020 (Japan Standard Time)

<Application Procedure>
see IRCMS website for detail

http://ircms.kumamoto-u.ac.jp/internship/

PUBLICATION

2020.7.23

Our paper is published! Congrats, Lal for your nice work.

Oinam L, Changarathil G, Raja E, Yen Ngo YX, Tateno H*, Sada A*, Yanagisawa H: Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging.

Aging Cell, e13190, 2020. *corresponding authors.

doi: 10.1111/acel.13190

https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13190

EurekAlert! AAAS

Skin Stem Cells Shuffle Sugars as They Age

https://www.eurekalert.org/pub_releases/2020-07/uot-ssc072120.php

Please check our news as well.

https://www.aikosada.com/post/glycan-profiling-of-epidermal-stem-cells-during-aging

FUNDING

2020.4.1

Aiko received JSPS KEKENHI, Grant-in-Aid for Scientific Research(B).

LAB NEWS

2020.4.1

Ph.D. student Yen and technician Takako have joined! 

https://www.aikosada.com/members

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熊本大学

国際先端医学研究機構(IRCMS)

​特任准教授

佐田亜衣子

E-mail: aisada (at) kumamoto-u.ac.jp

 

860-0811

熊本県熊本市中央区本荘2-2-1

Aiko Sada, Ph.D.

Associate Professor

International Research Center for Medical Sciences (IRCMS), Kumamoto University

 

E-mail: aisada (at) kumamoto-u.ac.jp


2-1-1 Honjo, Chuo-ku, Kumamoto City

860-0811, Japan

©︎2019, Sada Laboratory, IRCMS, Kumamoto University.  ©2010 kumamoto pref. kumamon. #K32035