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Welcome to the Sada Lab


Laboratory of Skin Regeneration and Aging

Medical Institute of Bioregulation, Kyushu University


Tissue stem cells maintain tissue integrity during homeostasis and exhibit remarkable plasticity in response to stresses and injuries. A misregulation of stem cells leads to tissue dysfunction, such as impaired wound healing, chronic inflammation, tumorigenesis, and aging. Emerging evidence suggests that stem cell populations in adult tissues are heterogeneous and play distinct roles in physiological and pathological conditions. 


Our research focuses on elucidating the cellular dynamics and regulatory mechanisms of tissue stem cells during skin regeneration, inflammation and aging processes. We have identified a novel stem cell population in mouse skin epidermis (Sada et al., Nat Cell Biol 2016) and established genetic tools and molecular markers to analyze these cells in vivo. Such stem cell proliferative heterogeneity is shown to be present not only in mouse skin, but also in the other epithelial tissues of the eye and oral mucosa, as well as in human skin. We are now combining cellular and molecular biology methods, mouse genetics, omics analysis, bioengineering, and glycobiology to analyze the function of biomolecules involved in skin stem cell regulation. Our research goal is to identify the drivers and effectors of stem cell dysfunction; targeting these factors will allow us to prevent and treat diseases at the stem cell level, with potential applications in regenerative therapies and future treatments for cancer, aging, and other skin diseases.


The Sada Laboratory is looking for motivated students (master's and doctoral level), post-doctoral fellows, and collaborators worldwide. If you are interested in pursuing research with us, please do not hesitate to contact us.





Kazuyo, our secretary, and Wanqing, a PhD student, joined our lab in April. We are looking forward to working with the new members and make our research more exciting!



We moved our lab from Kumamoto University to Kyushu University. It was hard to believe that the lab was empty 4.5 years ago when I first started up the lab. So many packages! Thanks to the hard work of the lab members, we were able to transport our important samples without losing them, and the setup at Kyushu University proceeded at an amazing speed, and we were able to unpack almost all the boxes in one day. Thanks everyone!



Today we had our last lab lunch in Kumamoto. We are very grateful to Keida san, a technician, and Nagata san, an admin, who has suported us for many years!



Dr. Makoto Takeo joined our lab at the Medical Institute of Bioregulation, Kyushu University as an Associate Professor in January 2024. Makoto has long been engaged in research related to skin stem cells and tissue regeneration. We hope you will enjoy working together to make our research more exciting!



Keida san, a technician in our lab, received the award from MEXT (Minister of Education, Culture, Sports, Science and Technology). Congratulations! This award is given to individuals who have made outstanding contributions to clinical and research work in medical science. She has worked as a clinical laboratory technician and research assistant at Kumamoto University for more than 20 years! Our lab members sincerely thank her for her great support to our research.



We attended the Molecular Biology Conference in Kobe, Japan. It was very exciting meeting. Aiko gave a talk at the symposium on ECM and aging, and Mizuho gave a poster presentation. As Career Path Committee members, Aiko also led a panel discussion at the luncheon seminar and discussed about the values of Ph.D.



IRCMS symposium: Rise of Diversity in Science was held for two days at IRCMS, Kumamoto University. The theme of the symposium was diversity, and we had invited lectures and poster sessions by researchers with diverse topics, as well as a panel discussion during the power hour "Diversity for Discovery: Unlocking the Power of Different Perspectives”. Sada lab members actively participated and enjoyed the symposium. I think it was a good, stimulating meeting. Thank you to all the speakers and participants.

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