Welcome to the Sada Lab!
Laboratory of Skin Regeneration and Aging
IRCMS, Kumamoto University, Japan
Stem cells maintain tissue integrity during homeostasis and show remarkable plasticity to respond to various stress or damages of the tissue. Dysfunction or misregulation of stem cells leads to tissue dysfunction, including impaired wound healing, cancer, and aging. Emerging evidence suggests heterogeneous stem cell populations within adult tissues and their specific roles in physiological and pathological conditions. Our research focuses on elucidating the cellular dynamics and regulatory mechanisms of tissue-resident stem cells, especially using mouse epithelial tissues (skin, eyes, oral) as a model. We identified new stem cell populations in the mouse skin epidermis (Sada et al., Nat Cell Biol 2016) and established the genetic tools and molecular markers to analyze these cells in vivo. We are currently studying stem cells in tissue regeneration and aging by combining cell & molecular biology techniques, genetic engineering of mice, omics analysis, bioengineering, glycobiology, and so on. Our research goal is to reveal the drivers and effectors of stem cell dysfunction. Targeting these factors may prevent or cure diseases at the stem cell level, with implications for applications in regenerative therapy and future treatments of cancer, aging, and other disorders.
Sada lab seeks motivated students (master and Ph.D. level), postdocs, and collaborators worldwide. Particulaly, our university has a priority slot for MEXT application for studying aging as a PhD student. We also have fellowship and internship program to do research at IRCMS. If you're interested in pursuing research with us, please do not hesitate to contact me.
International Research Center for Medical Sciences (IRCMS) at Kumamoto University is a a cutting edge, research institute, especially focusing on stem cells, aging and cancer. Researchers in our institute enjoy Science and closely communicate with each other in a characteristic open lab system of our institute.
LIFE IN KUMAMOTO
Kumamoto University is located in the south part of Japan (Kyushu area) and is close to the city center with traditional Japanese castle, convenient living places, shopping mall and nice foods & drinks! Kumamoto also has beautiful nature within 1 hour drive distance, where you can enjoy Aso mountains, hot springs, fishing and many other outdoor activities.
Life in Kumamoto
We have new members in our lab. Hegazy from Egypt, Wency from China, and Thisakorn from Thailand arrived in Kumamoto. Two basic course students from the Faculty of Medicine are also here. Welcome to Sada Lab, enjoy science!
Sada lab welcomed new postdoc Mizuho and master's student Ikuto. Yen received her degree and became a postdoc in April.
PhD student Yen has successfully completed her doctoral thesis defense today and passed the final review for her degree. Big congratulations, Dr. Yen!!! Thanks for your great thesis work.
MEXT student Tomson has arrived safely in Kumamoto. Welcome to Japan!!
The 44th annual meeting of the Molecular Biology Society of Japan (MBSJ) in Yokohama, Japan. Aiko gave a talk in the session on extracellular matrix and Erna presented her poster. Nguyen and Yen also attended the conference. Thank you all for the great talks and discussion!
PhD student Wency has received a fellowship of Pioneering Research Initiated by the Next Generation (SPRING) Program at Kumamoto University. Congratulations!!
Three new doctoral students have joined the Sada Lab today. Welcome! I am looking forward to working together in Kumamoto soon.