Welcome to the Sada Lab
Laboratory of Skin Regeneration and Aging
Medical Institute of Bioregulation, Kyushu University
Tissue stem cells maintain tissue integrity during homeostasis and exhibit remarkable plasticity in response to stresses and injuries. A misregulation of stem cells leads to tissue dysfunction, such as impaired wound healing, chronic inflammation, tumorigenesis, and aging. Emerging evidence suggests that stem cell populations in adult tissues are heterogeneous and play distinct roles in physiological and pathological conditions.
Our research focuses on elucidating the cellular dynamics and regulatory mechanisms of tissue stem cells during skin regeneration, inflammation and aging processes. We have identified a novel stem cell population in mouse skin epidermis (Sada et al., Nat Cell Biol 2016) and established genetic tools and molecular markers to analyze these cells in vivo. Such stem cell proliferative heterogeneity is shown to be present not only in mouse skin, but also in the other epithelial tissues of the eye and oral mucosa, as well as in human skin. We are now combining cellular and molecular biology methods, mouse genetics, omics analysis, bioengineering, and glycobiology to analyze the function of biomolecules involved in skin stem cell regulation. Our research goal is to identify the drivers and effectors of stem cell dysfunction; targeting these factors will allow us to prevent and treat diseases at the stem cell level, with potential applications in regenerative therapies and future treatments for cancer, aging, and other skin diseases.
The Sada Laboratory is looking for motivated students (master's and doctoral level), post-doctoral fellows, and collaborators worldwide. If you are interested in pursuing research with us, please do not hesitate to contact us.
WHAT'S NEW
LAB NEW
2025.4.1
New members joined the lab in April. Welcome!
MEETING
2025.2. 28
Aiko and Hinata attended the Japan Skin Research Club (JSRC) in Kurashiki. This meeting brings together researchers from basic, clinical, and industrial sciences. It was a great opportunity to deepen our understanding of skin biology.
LAB NEWS
2024.12. 27
Today marked the last workday of 2024, so we enjoyed a year-end lunch at the lab. It was a busy year with the lab relocation, but I'm pleased we established a great research environment at Kyushu University. With new members joining, our team is becoming more vibrant. Let's continue our hard work and make 2025 another successful year!
LAB NEWS
2024.12.16
Aiya joined our lab as a special project faculty. Welcome to Fukuoka! I hope we can do exciting research together.
MEETING
2024.8.28
The retreat was held at the Medical Institute of Bioregulation (MIB), Kyushu University. Mizuho gave an oral presentation, and Wency, Thisakorn, and Trisha gave poster presentations. Wency received the Excellent Poster Presentation Award! Congratulations.
The retreat was a wonderful opportunity to learn about and discuss research in the institute and receive critical feedback on our work. We enjoyed meeting and interacting with people within the institute.
On the second day of the MIB retreat, a dodgeball tournament was held as a social event. We had a great time, and I would like to thank the organizers for such a wonderful meeting!
MEETING
2024.8.21
PhD student Wency attended the Gordon Research Conference - Epithelial stem cells and niches in Barcelona, Spain and gave an oral and poster presentations. It was her first international conference and it was a great experience. Many thanks for all the discussion and feedback!
LAB NEWS
2024.8.20
PhD students Trisha and Manh have successfully completed their interim presentations. Since they are both students affiliated with Kumamoto University, we returned to IRCMS to give presentations. We are grateful to have a good discussion with the thesis committee members. Now that we have more clearer picture of things to do to make our research project into a paper, we will continue to work on it.