Papers & Reviews


Ishii R, Yanagisawa H*, Sada A*: Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium. 

*Corresponding authors. ​

Development, 2020, in press. [PubMed] [Full Text]

Oinam L, Changarathil G, Raja E, Yen Ngo YX, Tateno H, Sada A*, Yanagisawa H: Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. 

* Corresponding author

Aging Cell, e13190, 2020. [PubMed] [Full Text] [EurekAlert! AAAS]

Kang S, Long K, Wang S, Sada A, and Tumbar T: Histone H3 K4/9/27 trimethylation levels affect wound healing and stem cell dynamics in adult skin. 

Stem Cell Reports 14(1): 34-48, 2020 [PubMed] [Full Text]


Changarathil G, Ramirez K, Isoda H, Sada A*, Yanagisawa H: Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis. 

* Corresponding author

PLoS One 14(5): e0215908​, 2019 [PubMed] [Full Text] [Summary]

Oinam L, Changarathil G, Ngo YX, Yanagisawa H, Sada A*: Epidermal stem cell lineages. 

* Corresponding author

Advances in Stem Cells and their Niches, 2019 (A book chapter) [Full Text]

Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro Y, Kuro-O M, and Yanagisawa H: Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.

Matrix Biol 74: 5-20, 2018 [PubMed] [Full Text]

Sada A, Jain P, Wang S, Leung E, Tumbar T: Slc1a3-CreER as a targeting tool for the K6+ epithelial stem cell niche and its precursors during mouse hair follicle cycle.

J Invest Dermatol 137(7): 1569-1571, 2017 [PubMed] [Full Text] [Commentary]

Sada A, Jacob F, Leung E, Wang S, White BS, Shalloway D and Tumbar T: Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin.

Nat Cell Biol 18: 619-631, 2016. Selected for F1000 prime. [PubMed] [Full Text] [News@Weill Cornell]

Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, Saba R and Saga Y: RNA binding protein Nanos2 organizes post-transcriptional buffering system to retain primitive state of mouse spermatogonial stem cells. 

Dev Cell 34(1): 96-107, 2015 [PubMed] [Full Text]

Lee SE, Sada A, Zhang M, McDermitt DJ, Lu SY, Kemphues KJ and Tumbar T: High Runx1 levels promote a reversible, more-differentiated cell state in hair-follicle stem cells during quiescence. 

Cell Rep 6(3): 499-513, 2014 [PubMed] [Full Text]

Sada A and Tumbar T: New insights into mechanisms of stem cell daughter fate determination in regenerative tissues.

Int Rev Cell Mol Biol 300: 1-50, 2013 (A book chapter) [PubMed] [Full Text]

Sada A, Hasegawa K, Pin PH and Saga Y: NANOS2 acts downstream of glial cell line-derived neurotrophic factor signaling to suppress differentiation of spermatogonial stem cells. 

Stem Cells 30(2): 280-291, 2012 [PubMed] [Full Text]

Suzuki H, Saba R, Sada A and Saga Y: The Nanos3-3'UTR is required for germ cell specific NANOS3 expression in mouse embryos. 

PLoS One 5(2): e9300, 2010 [PubMed] [Full Text]

Suzuki H, Sada A, Yoshida S and Saga Y: The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. 

Dev Biol 336(2): 222-231, 2009 [PubMed] [Full Text]

Sada A, Suzuki A, Suzuki H and Saga Y: The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. 

Science 325(5946): 1394-1398, 2009 [PubMed] [Full Text]

Yamasaki H, Sada A, Iwata T, Niwa T, Tomizawa M, Xanthopoulos KG, Koike T and Shiojiri N: Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. 

Development 133(21): 4233-4243, 2006 [PubMed] [Full Text]

INVITED TALKS (international meeting) 

Sada A: Maintenance of heterogeneous epidermal stem cell populations by the distinct niche, Japan-Singapore International Skin Conference 2019, Singapore, April 10-12, 2019

Sada A: Defining the stem cell lineages in adult skin epidermis: CDB Symposium, Kobe, Japan, March 26-28, 2018

Sada A: Stem Cell Lineages of the Interfollicular Epidermis. Gordon Research Conference, Tissue Niches & Resident Stem Cells in Adult Epithelia, Hong Kong, China, August 7-12, 2016


Japan Agency for Medical Research and Development (AMED) /AMED-PRIME (JP20gm6110016), Elucidating the cellular and molecular mechanisms of epithelial stem cell aging, 52,000,000 yen, 2018 – 2021

Grant-in-Aid for Scientific Research (B) (20H03266). Molecular and cellular mechanisms to define the compartmentalization of epithelial stem cells, 2020 – 2023

Grant-in-Aid for Challenging Research (Exploratory) (20K21431). Elucidating the roles of cell surface glycans on epithelial stem cell aging, 2020 – 2021 


Grant-in-Aid for Scientific Research for Early-Career Scientists (18K14709), Epithelial stem cells: cellular dynamics and future use in regenerative therapy, 2018 – 2019

Grant-in-Aid for Scientific Research on Innovative Areas “Stem Cell Aging and Disease” (17H05631), Title: Stem cell aging in the skin epidermis: If stem cells divide more, do they age more?, 2017 – 2018

Grant-in-Aid for Scientific Research for Research Activity Start-up (16H06660), Epidermal stem cells: from homeostasis to aging, 2016

Interstellar Initiative/AMED, Elucidating the Cellular and Molecular Mechanisms of Stem Cell Aging, 2020

Nanotech CUPAL (Career-up Allicance)/Nanotech Research Professional (N.R.P.) course, Comprehensive glycome profiling of skin stem cells during aging, 2018 – 2019

Astellas Foundation for Research on Metabolic Disorders/Research grant, Elucidating the roles of cell surface glycans on skin stem cell aging, 2020 - 2021

The Mitsubishi Foundation/Research grant, Elucidating the roles of glycosylation during epidermal stem cell aging, 2020

The Ichiro Kanehara foundation/Research grant, Stem cell dynamics on the ocular surface epithelium, 2019

The Sumitomo foundation/Research grant, Identification of lectin biomarkers to define dynamic glycan alterations during epidermal stem cell aging, 2019

Takeda Science Foundation/Research grant, Bioengineering of stem cell niche, 2018

Naito Foundation/Research grant, Contribution of distinct cell populations during vascular remodeling, 2017 – 2019

Astellas Foundation for Research on Metabolic Disorders/Research grant, Mechanisms of epithelial stem cell aging: implication for future treatments of age-related disorders, 2018

Nakatomi Foundation/Research grant, Identification of lectin biomarkers for aged epidermal stem cells, 2018

Hoyu Science Foundation/Research grant, Identification of lectin biomarkers for aged epidermal stem cells, 2018

Nakajima Foundation/Research grant, Mechanisms of stem cell aging in the skin epidermis, 2017

Uehara Memorial Foundation/Research grant, Stem cell aging in the skin epidermis, 2017

Inamori Foundation/Research grant, Stem cell aging in the skin epidermis, 2017

SENSHIN Medical Research Foundation/Research grant, Elucidating the mechanisms of vascular remodeling: Search for putative stem/progenitor cells residing in adult vessels, 2017

Leave a Nest Co.,ltd. for IKEDARIKA award/Research grant, Stem cell aging in the skin epidermis,


Tsukuba Advanced Research Alliance (TARA Center), University of Tsukuba/The Cooperative Research Project Program of Life Science Center for Survival Dynamics, The roles of ECM protein Fibulin-7 in epidermal stem cell aging​, 2020

Gunma University/The joint research program of the Institure for Molecular and Cellular Regulation, Identification of metabolic factors regulating stem cell aging using the African turquoise killifish, 2019

Institute for Frontier Life and Medical Sciences, Kyoto University/Joint Usage/Research Center program, Stem cell dynamics in pregnant skin, 2017, 2019

University of Tsukuba/Basic Research Support Program Type A, Stem cell aging in the skin epidermis, 2016

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E-mail: aisada (at)




Aiko Sada, Ph.D.

Associate Professor

International Research Center for Medical Sciences (IRCMS), Kumamoto University


E-mail: aisada (at)

2-1-1 Honjo, Chuo-ku, Kumamoto City

860-0811, Japan

©︎2019, Sada Laboratory, IRCMS, Kumamoto University.  ©2010 kumamoto pref. kumamon. #K32035