Papers & Reviews


Oinam L, Changarathil G, Raja E, Yen Ngo YX, Tateno H, Sada A*, Yanagisawa H: Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. 

* Corresponding author

Aging Cell, e13190, 2020. [PubMed] [Full Text] [EurekAlert! AAAS]

Kang S, Long K, Wang S, Sada A, and Tumbar T: Histone H3 K4/9/27 trimethylation levels affect wound healing and stem cell dynamics in adult skin. 

Stem Cell Reports 14(1): 34-48, 2020 [PubMed] [Full Text]


Changarathil G, Ramirez K, Isoda H, Sada A*, Yanagisawa H: Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis. 

* Corresponding author

PLoS One 14(5): e0215908​, 2019 [PubMed] [Full Text] [Summary]

Oinam L, Changarathil G, Ngo YX, Yanagisawa H, Sada A*: Epidermal stem cell lineages. 

* Corresponding author

Advances in Stem Cells and their Niches, 2019 (A book chapter) [Full Text]

Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro Y, Kuro-O M, and Yanagisawa H: Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.

Matrix Biol 74: 5-20, 2018 [PubMed] [Full Text]

Sada A, Jain P, Wang S, Leung E, Tumbar T: Slc1a3-CreER as a targeting tool for the K6+ epithelial stem cell niche and its precursors during mouse hair follicle cycle.

J Invest Dermatol 137(7): 1569-1571, 2017 [PubMed] [Full Text] [Commentary]

Sada A, Jacob F, Leung E, Wang S, White BS, Shalloway D and Tumbar T: Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin.

Nat Cell Biol 18: 619-631, 2016. Selected for F1000 prime. [PubMed] [Full Text] [News@Weill Cornell]

Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, Saba R and Saga Y: RNA binding protein Nanos2 organizes post-transcriptional buffering system to retain primitive state of mouse spermatogonial stem cells. 

Dev Cell 34(1): 96-107, 2015 [PubMed] [Full Text]

Lee SE, Sada A, Zhang M, McDermitt DJ, Lu SY, Kemphues KJ and Tumbar T: High Runx1 levels promote a reversible, more-differentiated cell state in hair-follicle stem cells during quiescence. 

Cell Rep 6(3): 499-513, 2014 [PubMed] [Full Text]

Sada A and Tumbar T: New insights into mechanisms of stem cell daughter fate determination in regenerative tissues.

Int Rev Cell Mol Biol 300: 1-50, 2013 (A book chapter) [PubMed] [Full Text]

Sada A, Hasegawa K, Pin PH and Saga Y: NANOS2 acts downstream of glial cell line-derived neurotrophic factor signaling to suppress differentiation of spermatogonial stem cells. 

Stem Cells 30(2): 280-291, 2012 [PubMed] [Full Text]

Suzuki H, Saba R, Sada A and Saga Y: The Nanos3-3'UTR is required for germ cell specific NANOS3 expression in mouse embryos. 

PLoS One 5(2): e9300, 2010 [PubMed] [Full Text]

Suzuki H, Sada A, Yoshida S and Saga Y: The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. 

Dev Biol 336(2): 222-231, 2009 [PubMed] [Full Text]

Sada A, Suzuki A, Suzuki H and Saga Y: The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. 

Science 325(5946): 1394-1398, 2009 [PubMed] [Full Text]

Yamasaki H, Sada A, Iwata T, Niwa T, Tomizawa M, Xanthopoulos KG, Koike T and Shiojiri N: Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. 

Development 133(21): 4233-4243, 2006 [PubMed] [Full Text]


Sada A: Maintenance of heterogeneous epidermal stem cell populations by the distinct niche, Japan-Singapore International Skin Conference 2019, Singapore, April 10-12, 2019

Sada A: Defining the stem cell lineages in adult skin epidermis: CDB Symposium, Kobe, Japan, March 26-28, 2018

Sada A: Stem Cell Lineages of the Interfollicular Epidermis. Gordon Research Conference, Tissue Niches & Resident Stem Cells in Adult Epithelia, Hong Kong, China, August 7-12, 2016


Japan Agency for Medical Research and Development (AMED) /AMED-PRIME (JP19gm6110016), Elucidating the cellular and molecular mechanisms of epithelial stem cell aging, 52,000,000 yen, 2018 – 2022

Grant-in-Aid for Scientific Research (B) (20H03266). Molecular and cellular mechanisms to define the compartmentalization of epithelial stem cells, 2020 – 2024. 


Grant-in-Aid for Scientific Research for Early-Career Scientists (18K14709), Epithelial stem cells: cellular dynamics and future use in regenerative therapy, 2018 – 2020

Grant-in-Aid for Scientific Research on Innovative Areas “Stem Cell Aging and Disease” (17H05631), Title: Stem cell aging in the skin epidermis: If stem cells divide more, do they age more?, 2017 – 2019

Grant-in-Aid for Scientific Research for Research Activity Start-up (16H06660), Epidermal stem cells: from homeostasis to aging, 2016 – 2017

Nanotech CUPAL (Career-up Allicance)/Nanotech Research Professional (N.R.P.) course, Comprehensive glycome profiling of skin stem cells during aging, 2018 – 2019

The Mitsubishi Foundation/Research grant, Elucidating the roles of glycosylation during epidermal stem cell aging, 2019 – 2020

The Ichiro Kanehara foundation/Research grant, Stem cell dynamics on the ocular surface epithelium,

2019 – 2020

The Sumitomo foundation/Research grant, Identification of lectin biomarkers to define dynamic glycan alterations during epidermal stem cell aging, 2019 – 2020

Takeda Science Foundation/Research grant, Bioengineering of stem cell niche, 2018 – 2019

Naito Foundation/Research grant, Contribution of distinct cell populations during vascular remodeling, 2017 – 2019

Astellas Foundation for Research on Metabolic Disorders/Research grant, Mechanisms of epithelial stem cell aging: implication for future treatments of age-related disorders, 2018 – 2019

Nakatomi Foundation/Research grant, Identification of lectin biomarkers for aged epidermal stem cells, 2018 – 2019

Hoyu Science Foundation/Research grant, Identification of lectin biomarkers for aged epidermal stem cells, 2018 – 2019

Nakajima Foundation/Research grant, Mechanisms of stem cell aging in the skin epidermis, 2017 – 2018

Uehara Memorial Foundation/Research grant, Stem cell aging in the skin epidermis, 2017 – 2018

Inamori Foundation/Research grant, Stem cell aging in the skin epidermis, 2017 – 2018

SENSHIN Medical Research Foundation/Research grant, Elucidating the mechanisms of vascular remodeling: Search for putative stem/progenitor cells residing in adult vessels, 2017

Leave a Nest Co.,ltd. for IKEDARIKA award/Research grant, Stem cell aging in the skin epidermis,

2016 – 2017 

Gunma University/The joint research program of the Institure for Molecular and Cellular Regulation, Identification of metabolic factors regulating stem cell aging using the African turquoise killifish, 2019 – 2020

Institute for Frontier Life and Medical Sciences, Kyoto University/Joint Usage/Research Center program, Stem cell dynamics in pregnant skin, 2018 – 2020

University of Tsukuba/Basic Research Support Program Type A, Stem cell aging in the skin epidermis, 2016 – 2017

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E-mail: aisada (at)




Aiko Sada, Ph.D.

Associate Professor

International Research Center for Medical Sciences (IRCMS), Kumamoto University


E-mail: aisada (at)

2-1-1 Honjo, Chuo-ku, Kumamoto City

860-0811, Japan

©︎2019, Sada Laboratory, IRCMS, Kumamoto University.  ©2010 kumamoto pref. kumamon. #K32035