Papers & Reviews


Ishii R, Yanagisawa H*, Sada A*: Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium. 

*Corresponding authors. ​

Development, 2020, in press. [PubMed] [Full Text]

Oinam L, Changarathil G, Raja E, Yen Ngo YX, Tateno H, Sada A*, Yanagisawa H: Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. 

* Corresponding author

Aging Cell, e13190, 2020. [PubMed] [Full Text] [EurekAlert! AAAS]

Kang S, Long K, Wang S, Sada A, and Tumbar T: Histone H3 K4/9/27 trimethylation levels affect wound healing and stem cell dynamics in adult skin. 

Stem Cell Reports 14(1): 34-48, 2020 [PubMed] [Full Text]


Changarathil G, Ramirez K, Isoda H, Sada A*, Yanagisawa H: Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis. 

* Corresponding author

PLoS One 14(5): e0215908​, 2019 [PubMed] [Full Text] [Summary]

Oinam L, Changarathil G, Ngo YX, Yanagisawa H, Sada A*: Epidermal stem cell lineages. 

* Corresponding author

Advances in Stem Cells and their Niches, 2019 (A book chapter) [Full Text]

Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro Y, Kuro-O M, and Yanagisawa H: Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.

Matrix Biol 74: 5-20, 2018 [PubMed] [Full Text]

Sada A, Jain P, Wang S, Leung E, Tumbar T: Slc1a3-CreER as a targeting tool for the K6+ epithelial stem cell niche and its precursors during mouse hair follicle cycle.

J Invest Dermatol 137(7): 1569-1571, 2017 [PubMed] [Full Text] [Commentary]

Sada A, Jacob F, Leung E, Wang S, White BS, Shalloway D and Tumbar T: Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin.

Nat Cell Biol 18: 619-631, 2016. Selected for F1000 prime. [PubMed] [Full Text] [News@Weill Cornell]

Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, Saba R and Saga Y: RNA binding protein Nanos2 organizes post-transcriptional buffering system to retain primitive state of mouse spermatogonial stem cells. 

Dev Cell 34(1): 96-107, 2015 [PubMed] [Full Text]

Lee SE, Sada A, Zhang M, McDermitt DJ, Lu SY, Kemphues KJ and Tumbar T: High Runx1 levels promote a reversible, more-differentiated cell state in hair-follicle stem cells during quiescence. 

Cell Rep 6(3): 499-513, 2014 [PubMed] [Full Text]

Sada A and Tumbar T: New insights into mechanisms of stem cell daughter fate determination in regenerative tissues.

Int Rev Cell Mol Biol 300: 1-50, 2013 (A book chapter) [PubMed] [Full Text]

Sada A, Hasegawa K, Pin PH and Saga Y: NANOS2 acts downstream of glial cell line-derived neurotrophic factor signaling to suppress differentiation of spermatogonial stem cells. 

Stem Cells 30(2): 280-291, 2012 [PubMed] [Full Text]

Suzuki H, Saba R, Sada A and Saga Y: The Nanos3-3'UTR is required for germ cell specific NANOS3 expression in mouse embryos. 

PLoS One 5(2): e9300, 2010 [PubMed] [Full Text]

Suzuki H, Sada A, Yoshida S and Saga Y: The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. 

Dev Biol 336(2): 222-231, 2009 [PubMed] [Full Text]

Sada A, Suzuki A, Suzuki H and Saga Y: The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. 

Science 325(5946): 1394-1398, 2009 [PubMed] [Full Text]

Yamasaki H, Sada A, Iwata T, Niwa T, Tomizawa M, Xanthopoulos KG, Koike T and Shiojiri N: Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. 

Development 133(21): 4233-4243, 2006 [PubMed] [Full Text]

INVITED TALKS (international meeting) 

Sada A: Maintenance of heterogeneous epidermal stem cell populations by the distinct niche, Japan-Singapore International Skin Conference 2019, Singapore, April 10-12, 2019

Sada A: Defining the stem cell lineages in adult skin epidermis: CDB Symposium, Kobe, Japan, March 26-28, 2018

Sada A: Stem Cell Lineages of the Interfollicular Epidermis. Gordon Research Conference, Tissue Niches & Resident Stem Cells in Adult Epithelia, Hong Kong, China, August 7-12, 2016


1. Japan Agency for Medical Research and Development (AMED) /AMED-PRIME (JP20gm6110016), October 2018 – March 2022

Title: Elucidating the cellular and molecular mechanisms of epithelial stem cell aging


2. Grant-in-Aid for Scientific Research/Grant-in-Aid for Scientific Research (B) (20H03266), April 2020 – March 2024

Title: Compartmentalization of epithelial stem cells in skin development and homeostasis


3. Grant-in-Aid for Scientific Research/ Grant-in-Aid for Challenging Research (Exploratory) (20K21431), July 2020 – March 2021

Title: Elucidating the roles of cell surface glycans on epithelial stem cell aging


4. Grant-in-Aid for Scientific Research/for Early-Career Scientists (18K14709), April 2018 – March 2020

Title: Oral epithelial stem cells: cellular dynamics and future use in regenerative therapy


5. Grant-in-Aid for Scientific Research/on Innovative Areas “Stem Cell Aging and Disease” (17H05631), April 2017 – March 2019

Title: Stem cell aging in the skin epidermis: If stem cells divide more, do they age more?


6. Grant-in-Aid for Scientific Research/for Research Activity Start-up (16H06660), October 2016 – March 2017

Title: Epidermal stem cells: from homeostasis to aging


7. Nanotech CUPAL (Career-up Allicance) /Nanotech Research Professional (N.R.P.) course, April 2018 – March 2019

Title: Comprehensive glycome profiling of skin stem cells during aging


8. Japan Agency for Medical Research and Development (AMED) /Interstellar Initiative, September 2020 – March 2021

Title: Elucidating the Cellular and Molecular Mechanisms of Stem Cell Aging


9. Naito Foundation/Research grant, April 2021 – March 2024

Title: Contribution of distinct stem cell populations in age-related skin dysfunction


10. Astellas Foundation for Research on Metabolic Disorders/Research grant, October 2020 – September 2022

Title: Elucidating the roles of cell surface glycans on skin stem cell aging


11. The Senri Life Science Foundation/Research grant, April 2021 – March 2022

Title: Mechanisms of glycomeshift in epidermal stem cell aging


12. Uehara Memorial Foundation/Research grant, January 2021 – March 2022

Title: Elucidating the role of stem cell heterogeneity and bioengineering of 3D skin


13. Tokyo Biochemical Research Foundation/Research grant, April 2021 – March 2022

Title: Elucidating the roles of cell surface glycans on skin stem cell aging


14. The Mitsubishi Foundation/Research grant, October 2019 – March 2021

Title: Dynamic changes in protein glycosylation in skin regeneration and aging


15. The Sumitomo foundation/Research grant, October 2019 – November 2021

Title: Identification of lectin biomarkers to define dynamic glycan alterations during epidermal stem cell aging


16. The Ichiro Kanehara foundation/Research grant, October 2019 – September 2020, Aiko Sada, 700,000 yen

Title: Stem cell dynamics on the ocular surface epithelium

  • YouTube
  • Facebook
  • Twitterの社会のアイコン
  • Instagram
  • アイコン-3





E-mail: aisada (at)




Aiko Sada, Ph.D.

Associate Professor

International Research Center for Medical Sciences (IRCMS), Kumamoto University


E-mail: aisada (at)

2-1-1 Honjo, Chuo-ku, Kumamoto City

860-0811, Japan

©︎2019, Sada Laboratory, IRCMS, Kumamoto University.  ©2010 kumamoto pref. kumamon. #K32035