Takeo, M., Toyoshima, K., Fujimoto, R., Iga, T., Takase, M., Ogawa, M., Tsuji, T. Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair. Nat. Commun. 4;14(1):4478, 2023. [PubMed] [Full Text]

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Raja E, Changarathil G, Oinam L, Tsunezumi J, Ngo YX, Ishii R, Sasaki T, Imanaka-Yoshida K, Yanagisawa H*, Sada A*: The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging. EMBO Rep. e55478, 2022. [PubMed] [Full Text]

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Ngo YX, Haga K, Suzuki A, Kato H, Yanagisawa H, Izumi K, Sada A*: Isolation and culture of primary oral keratinocytes from the adult mouse palate. J Vis Exp, (175): e62820, 2021. [PubMed] [Full Text]

Kimura K, Ramirez K, Nguyen TAV, Yamashiro Y, Sada A and Yanagisawa H: Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels. Sci Rep, 11(1):8683, 2021. [PubMed] [Full Text]

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Ichijo R, Kabata M, Kidoya H, Muramatsu F, Ishibashi R, Abe K, Tsutsui K, Kubo H, Iizuka Y, Kitano S, Miyachi H, Kubota Y, Fujiwara H, Sada A, Yamamoto T, Toyoshima F: Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs. Science Advances, 7(7): eabd2575, 2021.[PubMed] [Full Text]

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Takeo, M., Asakawa, K., Toyoshima, K., Ogawa, M., Tong, JJ., Irié, T., Yanagisawa, M., Sato, A. and Tsuji, T: Expansion and characterization of epithelial stem cells with organ-inductive potential for long-term cyclical hair regeneration. Sci Rep, 11(1):1173, 2021. [PubMed] [Full Text]

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Ishii R, Yanagisawa H*, Sada A*: Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium. 

*Corresponding authors. ​

Development, 147(24):dev197590, 2020. [PubMed] [Full Text]

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Oinam L, Changarathil G, Raja E, Yen Ngo YX, Tateno H, Sada A*, Yanagisawa H: Glycome profiling by lectin microarray reveals dynamic glycan alterations during epidermal stem cell aging. 

* Corresponding author

Aging Cell, e13190, 2020. [PubMed] [Full Text] [EurekAlert! AAAS]

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Kang S, Long K, Wang S, Sada A, and Tumbar T: Histone H3 K4/9/27 trimethylation levels affect wound healing and stem cell dynamics in adult skin. 

Stem Cell Reports 14(1): 34-48, 2020 [PubMed] [Full Text]

Changarathil G, Ramirez K, Isoda H, Sada A*, Yanagisawa H: Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis. 

* Corresponding author

PLoS One 14(5): e0215908​, 2019 [PubMed] [Full Text] [Summary]

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Oinam L, Changarathil G, Ngo YX, Yanagisawa H, Sada A*: Epidermal stem cell lineages. 

* Corresponding author

Advances in Stem Cells and their Niches, 2019 (A book chapter) [Full Text]

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Tsunezumi J, Sugiura H, Oinam L, Ali A, Thang BQ, Sada A, Yamashiro Y, Kuro-O M, and Yanagisawa H: Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.

Matrix Biol 74: 5-20, 2018 [PubMed] [Full Text]

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Sada A, Jain P, Wang S, Leung E, Tumbar T: Slc1a3-CreER as a targeting tool for the K6+ epithelial stem cell niche and its precursors during mouse hair follicle cycle.

J Invest Dermatol 137(7): 1569-1571, 2017 [PubMed] [Full Text] [Commentary]

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Sada A, Jacob F, Leung E, Wang S, White BS, Shalloway D and Tumbar T: Defining the cellular lineage hierarchy in the interfollicular epidermis of adult skin.

Nat Cell Biol 18: 619-631, 2016. Selected for F1000 prime. [PubMed] [Full Text] [News@Weill Cornell]

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Takeo, M., Lee, W., Rabbani, R., Sun, Q., Hu, H., Lim, CH, Manga, P. and Ito, M. EdnrB governs regenerative response of melanocyte stem cells by crosstalk with Wnt signaling. Cell Reports 15(6):1291-302. 2016.

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Takeo, M., Hale, C.S, and Ito, M. Epithelium-derived Wnt ligands are essential for maintenance of underlying digit bone. J Invest Dermatol. 136(7):1355-63. 2016.

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Takeo, M., Chou, W.C., Sun, Q., Lee, W., Rabbani, P., Loomis, C., M. Taketo, M.M, and Ito. M. Wnt activation in nail epithelium couples nail growth to digit regeneration. Nature. 499:228-32. 2013

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Rabbani, P.*, Takeo, M.*, Chou., W.C., Myung, P., Taketo, M.M., Chin, L., Bosenberg, M., and Ito, M. Ito.  Coordinated activation of Wnt signaling in epithelial and melanocyte stem cells initiates pigmented hair follicle regeneration. Cell. 145:941-55. 2011. (*co-first author)

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Zhou Z, Shirakawa T, Ohbo K, Sada A, Wu Q, Hasegawa K, Saba R and Saga Y: RNA binding protein Nanos2 organizes post-transcriptional buffering system to retain primitive state of mouse spermatogonial stem cells. 

Dev Cell 34(1): 96-107, 2015 [PubMed] [Full Text]

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Lee SE, Sada A, Zhang M, McDermitt DJ, Lu SY, Kemphues KJ and Tumbar T: High Runx1 levels promote a reversible, more-differentiated cell state in hair-follicle stem cells during quiescence. 

Cell Rep 6(3): 499-513, 2014 [PubMed] [Full Text]

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Sada A and Tumbar T: New insights into mechanisms of stem cell daughter fate determination in regenerative tissues.

Int Rev Cell Mol Biol 300: 1-50, 2013 (A book chapter) [PubMed] [Full Text]

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Sada A, Hasegawa K, Pin PH and Saga Y: NANOS2 acts downstream of glial cell line-derived neurotrophic factor signaling to suppress differentiation of spermatogonial stem cells. 

Stem Cells 30(2): 280-291, 2012 [PubMed] [Full Text]

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Suzuki H, Saba R, Sada A and Saga Y: The Nanos3-3'UTR is required for germ cell specific NANOS3 expression in mouse embryos. 

PLoS One 5(2): e9300, 2010 [PubMed] [Full Text]

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Suzuki H, Sada A, Yoshida S and Saga Y: The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. 

Dev Biol 336(2): 222-231, 2009 [PubMed] [Full Text]

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Sada A, Suzuki A, Suzuki H and Saga Y: The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. 

Science 325(5946): 1394-1398, 2009 [PubMed] [Full Text]

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Yamasaki H, Sada A, Iwata T, Niwa T, Tomizawa M, Xanthopoulos KG, Koike T and Shiojiri N: Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. 

Development 133(21): 4233-4243, 2006 [PubMed] [Full Text]